"Add an extra charge of your Special skill. Corrupts all Fuel Cells." The in-game tooltip is incomplete. Lysate Cell also reduces your Special skill cooldown by 33% - an undocumented effect confirmed by both major wikis. It is the void counterpart to the Fuel Cell, shifting the bonus from equipment to your Special skill slot. On pickup it corrupts every Fuel Cell you hold.
The in-game description only mentions the extra charge. Lysate Cell also reduces your Special skill cooldown by 33% - this effect is not displayed anywhere in-game. Both riskofrain2.wiki.gg and the Fandom wiki confirm this. The CDR is a flat 33% regardless of stack count.
If you have no strong equipment, Lysate Cell is almost always better - your Special skill fires more often and the 33% CDR compounds with Alien Head and Purity. Pick Fuel Cell if you are running Gesture of the Drowned, Spinel Tonic, or any equipment build. If you already hold Fuel Cells, picking up Lysate Cell converts them all - make sure the trade is worth it before you commit.
MUL-T's Retool already has a 0.5s cooldown - the minimum - so the CDR does nothing and extra charges are irrelevant for a toggle skill. Captain's Orbital Supply Beacon resets per stage not per cooldown, so Lysate Cell provides no practical benefit in the stage it is collected and limited benefit afterward.
Purity stacks directly with Lysate Cell CDR. Purity reduces all skill cooldowns by a flat 2s per stack. Lysate Cell's 33% reduction and Purity's flat reduction apply together - on a 10s special cooldown that becomes about 4.3s (33% from Lysate, then -2s from Purity). Both target Special CD.
Alien Head multiplies the CDR further. Alien Head reduces all skill cooldowns by 25% per stack (hyperbolic). Combined with Lysate Cell's 33% flat reduction, the special cooldown compresses rapidly. 1 Alien Head + 1 Lysate Cell on a 10s cooldown = roughly 5s.
Hardlight Afterburner adds Utility charges; Lysate adds Special charges. Together they let you cycle both skill slots more aggressively. On Loader this means more Thunder Grapples and more Thunderslams in rapid succession.Lysate Cell is a void item that adds +1 charge to your Special skill per stack and reduces your Special skill cooldown by 33%. The cooldown reduction is not shown in the in-game description - it is an undocumented effect. On pickup it corrupts all Fuel Cells in your inventory. It is the void counterpart to the Fuel Cell, shifting the benefit from equipment to your Special skill.
Yes, but the game does not tell you this. Lysate Cell reduces your Special skill cooldown by 33% in addition to giving +1 charge. This is a flat reduction not shown in the item description, confirmed by both major RoR2 wikis. The cooldown reduction is fixed at 33% regardless of how many Lysate Cells you hold.
It depends entirely on your build. Fuel Cell is better for equipment-heavy builds - it stacks exponentially on equipment cooldown and synergizes with Gesture of the Drowned and Spinel Tonic. Lysate Cell is better when your Special skill is more valuable than your equipment, which is true for Railgunner, Acrid, Commando, and Bandit. If you have no notable equipment, Lysate Cell is almost always the better pick.
Railgunner gets the most value - an extra Supercharge charge effectively doubles her high-damage sniper output. Acrid benefits greatly from extra Epidemic charges to spread poison faster. Commando's Suppressive Fire with extra charges and attack speed is excellent. Bandit benefits from extra Lights Out or Desperado charges. MUL-T and Captain get little to no benefit.
Yes, and it has a unique interaction. Normally Ruin cannot apply Ruin stacks while on cooldown. With at least one Lysate Cell, Ruin can still be applied as long as at least one charge remains. This keeps the damage debuff active during the cooldown window, increasing sustained Ruin DPS significantly.
Lysate Cell is a void item obtainable from Void Cradles, Void Fields cell rewards, and Encrusted Key caches. With the Artifact of Command, it can be selected freely from void-tier Command Essences. It requires the Survivors of the Void DLC to appear in runs.